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SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans
Manganese (Mn) is an essential metal that can exert toxic effects at high concentrations, eventually leading to Parkinsonism. A major transporter of Mn in mammals is the divalent-metal transporter (DMT1). We characterize here DMT1-like proteins in the nematode C. elegans, which regulate and are regulated by Mn and iron (Fe) content. We identified three new DMT1-like genes in C. elegans: smf-1, ...
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ژورنال
عنوان ژورنال: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum
سال: 2012
ISSN: 1424-4020,1424-3784
DOI: 10.4414/smf.2012.01145